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Synthesis of resorcylic acid lactones useful as therapeutic agents
US9051302B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9051302-B2 |
| Application number | US-86312309-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 15, 2009 |
| Priority date | Jan 15, 2008 |
| Publication date | Jun 9, 2015 |
| Grant date | Jun 9, 2015 |
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Abstract
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Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound, or a tautomer thereof, a pharmaceutically acceptable salt, solvate, ester or prodrug thereof, selected from 2. A pharmaceutical composition comprising an effective HSP 90-inhibiting amount of a compound of claim 1 , in combination with a pharmaceutically acceptable carrier.
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Frequently asked questions
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- What does patent US9051302B2 cover?
- Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
- Who is the assignee on this patent?
- Winssinger Nicolas, Barluenga Sofia, Karplus Martin, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D405/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 09 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).