Process for the preparation of phenyl substituted 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid N-methoxy-[1-methyl-2 phenylethyl] amides

Patent metadata

Field	Value
Publication number	US-9051272-B2
Application number	US-201314374547-A
Country	US
Kind code	B2
Filing date	Feb 26, 2013
Priority date	Feb 28, 2012
Publication date	Jun 9, 2015
Grant date	Jun 9, 2015

Abstract

The invention relates to a process for the preparation of a compound of formula (I), wherein R 1 , R 2 and R 3 are as defined in claim 1 , which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R 4 —O—N═O (III)), wherein R 4 is C 1 -C 8 alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H 2 N—O—CH 3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C 1-6 alkoxy, to the compound of formula (I).

First claim

What is claimed is:

1. A process for the preparation of the compound of formula I

wherein
R 1 is hydrogen, halogen or C 1 -C 6 alkyl;
R 2 is hydrogen, halogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 6 alkinyl, C 3 -C 6 cycloalkyl-C 3 -C 6 alkinyl, halophenoxy, halophenyl-C 3 -C 6 alkinyl, C(C 1 -C 4 alkyl)=NO—C 1 -C 4 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6…

Assignees

• Syngenta Participations Ag

Inventors

• Stierli Daniel
• Walter Harald
• Rommel Michael
• Hanreich Reinhard Georg
• Zeller Martin
• Vettiger Thomas
• Smejkal Tomas

Classifications

• C07D231/14 Primary

  Chemistry & Metallurgy · mapped topic

• C07D231/12 Primary

  Chemistry & Metallurgy · mapped topic