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Modified small activating RNA molecules and methods of use
US9045751B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9045751-B2 |
| Application number | US-201113096817-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 28, 2011 |
| Priority date | Apr 28, 2010 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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- Title
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Abstract
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Methods, compositions and kits are provided for increasing the expression of a gene product in a cell by contacting the cell with a modified small activating RNA (saRNA) molecule, which provides for an increase in gene expression that is improved over the increase in expression provided by traditional saRNAs. These methods and compositions find use in any application in which an increase in gene expression in a cell is desired.
First claim
Opening claim text (preview).
That which is claimed is: 1. A method for increasing the expression of a p21 gene in a cell, the method comprising: introducing into a cell an effective amount of a modified p21 gene-specific small activating RNA (saRNA), the modified p21 gene-specific saRNA comprising: i. an antisense strand comprising a mismatch at the 5′ terminal nucleotide compared to antisense strand of a p21 gene-specific control saRNA; and ii. a sense strand of the p21 gene-specific control saRNA, the se…
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- C12N15/113Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9045751B2 cover?
- Methods, compositions and kits are provided for increasing the expression of a gene product in a cell by contacting the cell with a modified small activating RNA (saRNA) molecule, which provides for an increase in gene expression that is improved over the increase in expression provided by traditional saRNAs. These methods and compositions find use in any application in which an increase in gen…
- Who is the assignee on this patent?
- Place Robert F, Li Long-Cheng, Univ California
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).