St2 antigen binding proteins
US-2024368292-A1 · Nov 7, 2024 · US
Methods of using antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
US9045547B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9045547-B2 |
| Application number | US-201113251909-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 3, 2011 |
| Priority date | Aug 23, 2007 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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Abstract
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Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
First claim
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What is claimed is: 1. A method for treating hypercholesterolemia in a patient, said method comprising administering to a patient in need thereof a therapeutically effective amount of a monoclonal antibody that binds to PCSK9, wherein the monoclonal antibody binds to an epitope on PCSK9 comprising at least one of the following residues: S153, I154, P155, R194, D238, A239, I369, S372, D374, C375, T377, F379, V380, or S381 of SEQ ID NO: 3, and wherein the monoclonal antibody blocks b…
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- What does patent US9045547B2 cover?
- Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
- Who is the assignee on this patent?
- Jackson Simon Mark, Walker Nigel Pelham Clinton, Piper Derek Evan, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/395. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).