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Small molecule conjugates with dimetal species for protein inhibition
US9045527B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9045527-B2 |
| Application number | US-201313916359-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 12, 2013 |
| Priority date | Jun 12, 2012 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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- Title
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Abstract
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Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.
First claim
Opening claim text (preview).
What is claimed is: 1. A method comprising: introducing to a target protein a compound comprising a peptide ligand from the PDZ domain of a cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand wherein the peptide ligand is covalently linked to a rhodium(II) complex and wherein the compound binds to the target protein and form stabilizing secondary contacts between the rhodium(II) complex and the target protein. 2. A method comprising: introducing to a target protein a compound comprising a peptide covalently linked to a rhodium(II) complex, wherein the peptide comprises a sequence selected from the group consisting of SEQ ID NO: 7, SEQ ID NO: 8, and SEQ ID NO: 15, and wherein the compound binds to the target protein and forms stabilizing secondary contacts between the rhodium(II) complex and the target protein. 3. The method of claim 2 , wherein the sequence is SEQ ID NO: 7. 4. The method of claim 2 , wherein the sequence is SEQ ID NO: 8. 5. The method of claim 2 , wherein the sequence is SEQ ID NO: 15.
Assignees
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Classifications
- C07K1/107Primary
by chemical modification of precursor peptides · CPC title
- C07K1/1075Primary
by covalent attachment of amino acids or peptide residues · CPC title
Human Necessities · mapped topic
the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient · CPC title
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- What does patent US9045527B2 cover?
- Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and…
- Who is the assignee on this patent?
- Univ Rice William M, Dartmouth College
- What technology area does this patent fall under?
- Primary CPC classification C07K1/107. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).