Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease

Patent metadata

Field	Value
Publication number	US-9045486-B2
Application number	US-201414149284-A
Country	US
Kind code	B2
Filing date	Jan 7, 2014
Priority date	Jan 8, 2013
Publication date	Jun 2, 2015
Grant date	Jun 2, 2015

Abstract

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof,

which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

First claim

The invention claimed is:

1. A compound having the formula (I),

wherein
X 10 is NR 15 , N(R 15 )C(O), C(O)NR 15 , O, C(O), C(O)O, OC(O); N(R 15 )SO 2 , SO 2 N(R 15 ), S, SO, or SO 2 ;
R 10 is —H, a —C 1-6 alkyl group or a —C(O)—C 1-6 alkyl group;
R 11 is —H, a —C 1-6 alkyl group, or a —C 1-6 alkyl group which is substituted by one or more ha…

Assignees

• Savira Pharmaceuticals Gmbh
• European Molecular Biology Lab Embl
• Hoffmann La Roche
• Hoffmann La Roche

Inventors

• Wolkerstorfer Andrea
• Szolar Oliver
• Handler Norbert
• Buschmann Helmut
• Cusack Stephen
• Smith Mark
• So Sung-Sau
• Hawley Ronald Charles
• Sidduri Achyutharao
• Zhang Zhuming

Classifications

• A61P31/16

  Human Necessities · mapped topic

• A61P31/12

  Human Necessities · mapped topic

• A61P31/22

  Human Necessities · mapped topic

• A61P31/14

  Human Necessities · mapped topic

• C07D403/04 Primary

  Chemistry & Metallurgy · mapped topic