Substituted 6,5-fused bicyclic heteroaryl compounds

Patent metadata

Field	Value
Publication number	US-9045477-B2
Application number	US-201414211248-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	Jun 2, 2015
Grant date	Jun 2, 2015

Abstract

The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

First claim

What is claimed is:

1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

wherein
X 1 is NR 7 or CR 7 ;
X 2 is N, NR 8 , CR 8 , O, or S;
X 3 is NR 8 , CR 8 , O, or S;
X 4 is C;
Y 1 is N;
Y 2 is CR 6 ;
Y 3 is CR 11 ;
each of R 5 , R 9 , and R 10 , independently, is H or C 1 -C 6 alkyl optionally substituted with one or more substitue…

Assignees

• Epizyme Inc

Inventors

• Campbell John Emmerson
• Kuntz Kevin Wayne

Classifications

• C07D401/14

  Chemistry & Metallurgy · mapped topic

• C07D413/12

  Chemistry & Metallurgy · mapped topic

• C07D403/12

  Chemistry & Metallurgy · mapped topic

• C07D417/12

  Chemistry & Metallurgy · mapped topic

• C07D519/00

  Chemistry & Metallurgy · mapped topic