Affinity Chromatography Media and Chromatography Devices
US-2016332142-A1 · Nov 17, 2016 · US
US9044740B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9044740-B2 |
| Application number | US-59400208-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 20, 2008 |
| Priority date | Mar 30, 2007 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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Official abstract text for this publication.
The present invention relates to a separation matrix comprised of a porous or non-porous support to which ligands have been immobilized, wherein said ligands comprise at least one aliphatic sulfamide. The invention also relates to a chromatography column that contains the described separation matrix, as well as to a method of isolating immunoglobulins, such as IgG, Fab fragments, fusion proteins containing immunoglobulins etc, by adsorption to a separation matrix that comprises the aliphatic sulfamide ligands of the invention.
Opening claim text (preview).
What is claimed is: 1. A separation matrix comprised of a support to which at least one ligand has been covalently immobilized, optionally via a spacer arm, wherein said ligand comprises one aliphatic sulfamide group described by the following formula: —N(R 1 )—S(O) 2 —N(R 2 )(R 3 ) (I) wherein R 1 , R 2 and R 3 are, independently from each other, either hydrogen or linear, optionally branched carbon chains, and wherein the content of aliphatic sulfamide groups is…
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