Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides
US-9221888-B2 · Dec 29, 2015 · US
Fabrication of bone regeneration scaffolds and bone filler material using a perfusion flow system
US9044530B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9044530-B2 |
| Application number | US-201213720543-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 19, 2012 |
| Priority date | Dec 19, 2012 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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Abstract
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The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.
First claim
Opening claim text (preview).
What is claimed is: 1. A process to form a bone grafting material, comprising: providing a porous collagen scaffold; inserting the collagen scaffold into a perfusion chamber of a perfusion flow system; continuously providing a mineralization perfusion fluid flow comprising polyaspartic acid through the collagen scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the collagen scaffold; forming a collagen/hydroxyapatite composite scaffold; contacting…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A61L27/46Primary
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US9044530B2 cover?
- The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and fo…
- Who is the assignee on this patent?
- Southwest Res Inst
- What technology area does this patent fall under?
- Primary CPC classification A61L27/46. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).