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Amyloid peptide inactivating enzyme to treat alzheimer's disease peripherally
US9044503B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9044503-B2 |
| Application number | US-66127405-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 26, 2005 |
| Priority date | Aug 27, 2004 |
| Publication date | Jun 2, 2015 |
| Grant date | Jun 2, 2015 |
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Abstract
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Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.
First claim
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What is claimed is: 1. A method for reducing amyloid peptide in the brain of a patient in need thereof, said method comprising: (a) generating a non-replicating recombinant viral vector comprising a nucleotide sequence encoding neprilysin operably linked to a promoter; (b) obtaining hematopoietic stem cells from the patient; (c) introducing the non-replicating recombinant viral vector into the hematopoietic stem cells, ex vivo; and (d) introducing the hematopoietic stem cell…
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Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K48/00Primary
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9044503B2 cover?
- Methods for treatment and/or prevention of Alzheimer's disease comprising inactivating peripheral AP in serum to a reduce A(3 in the brain. Methods comprise expression of amyloid peptide inactivating enzyme on bone marrow cells; and coupling of amyloid peptide inactivating enzyme to hematopoietic cells.
- Who is the assignee on this patent?
- Hersh Louis B, Guan Hanjun, Univ Kentucky Res Found
- What technology area does this patent fall under?
- Primary CPC classification A61K48/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 02 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).