Metabolic imprinting effects of structured lipids

Patent metadata

Field	Value
Publication number	US-9044446-B2
Application number	US-201013514934-A
Country	US
Kind code	B2
Filing date	Nov 30, 2010
Priority date	Dec 11, 2009
Publication date	Jun 2, 2015
Grant date	Jun 2, 2015

Abstract

The invention relates to the use of triglycerides which an enhanced portion of the palmitic acid residues in the sn-2 position for an early in life diet for improving the development of a healthy body composition, in particular prevention of obesity, later in life.

First claim

The invention claimed is:

1. A method for reducing the risk of obesity, and/or treating obesity, comprising administering a human subject in need thereof a nutritional composition comprising an effective amount of triglycerides, wherein the triglycerides comprise at least 10 wt. % of palmitic acid residues, based on total fatty acid residues present in the triglycerides, wherein at least 30 wt. % of the palmitic acid residues are in the sn-2 position of the triglycerides, based on total palmitic acid residues, and wherein the composition does not comprise human milk.

2. The method according to claim 1 , wherein the human subject is between 0 and 36 months of age.

3. The method according to claim 1 , wherein the nutritional composition is administered to a human subject with an age between 0 and 36 months and obesity or its risk is reduced in the human subject at an age above 36 months.

4. The method according to claim 1 , wherein the nutritional composition is administered to a human subject with an age between 0 and 36 months and obesity or its risk is reduced in the human subject at an age above 5 years.

5. The method according to claim 1 , wherein the human subject is non-obese.

6. The method according to claim 1 , wherein the human subject is a preterm infant or an infant small for gestational age.

7. The method according to claim 1 , wherein the composition comprises 10 to 50 wt. % lipids based on dry weight of the total composition and wherein the lipid comprises from 80 to 100 wt. % triglycerides based on total lipid.

8. The method according to claim 7 , wherein the lipids comprise linoleic acid and alpha-linolenic acid at a linoleic acid to alpha-linolenic acid weight ratio between 4 and 7.

9. The method according to claim 1 , wherein the composition comprises lipids, digestible carbohydrates, and proteins, wherein said lipids provide 30 to 60% of the total calories, said protein provides 5 to 20% of the total calories and said digestible carbohydrates provide 25 to 75% of the total calories.

10. The method according to claim 1 , wherein the composition further comprises non-digestible oligosaccharides.

11. A method for increasing lean body mass, decreasing fat mass relative to total body weight, decreasing fat accumulation and/or increasing muscle mass, the method comprising administering to a human subject in need thereof a composition comprising an effective amount of triglycerides, wherein the triglycerides comprise at least 10 wt. % of palmitic acid residues, based on total fatty acid residues present in the triglycerides, wherein at least 30 wt. % of the palmitic acid residues are in the sn-2 position of the triglycerides, based on total palmitic acid residues, and wherein the composition does not comprise human milk.

12. The method according to claim 11 , wherein the human subject is between 0 and 36 months of age.

13. The method according to claim 11 , wherein the nutritional composition is administered to a human subject with an age between 0 and 36 months and lean body mass is increased, fat mass relative to total body weight is decreased, fat accumulation is decreased and/or muscle mass is increased in the human subject at an age above 36 months.

14. The method according to claim 11 , wherein the nutritional composition is administered to a human subject with an age between 0 and 36 months and obesity or its risk is reduced in the human subject at an age above 5 years.

15. The method according to claim 11 , wherein the composition comprises 10 to 50 wt. % lipids based on dry weight of the total composition and wherein the lipid comprises from 80 to 100 wt. % triglycerides based on total lipid.

16. The method according to claim 15 , wherein the lipids comprise linoleic acid and alpha-linolenic acid at a linoleic acid to alpha-linolenic acid weight ratio between 4 and 7.

17. The method according to claim 11 , wherein the composition comprises lipids, digestible carbohydrates, and proteins, wherein said lipids provide 30 to 60% of the total calories, said protein provides 5 to 20% of the total calories and said digestible carbohydrates provide 25 to 75% of the total calories.

18. The method according to claim 11 , wherein the composition further comprises non-digestible oligosaccharides.

Assignees

• Van Der Beek Eline Marleen
• Abrahamse-Berkeveld Marieke
• Oosting Annemarie
• Alles Martine Sandra
• Nutricia Nv

Inventors

• Van Der Beek Eline Marleen
• Abrahamse-Berkeveld Marieke
• Oosting Annemarie
• Alles Martine Sandra

Classifications

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61K31/215 Primary

  of carboxylic acids · CPC title

• A61K31/22

  of acyclic acids, e.g. pravastatin · CPC title