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US-12086960-B2 · Sep 10, 2024 · US
System and method for simultaneous detection of secondary electrons and light in a charged particle beam system
US9040909B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9040909-B2 |
| Application number | US-201213681746-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 20, 2012 |
| Priority date | Jan 30, 2011 |
| Publication date | May 26, 2015 |
| Grant date | May 26, 2015 |
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Abstract
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A method and system for the imaging and localization of fluorescent markers such as fluorescent proteins or quantum dots within biological samples is disclosed. The use of recombinant genetics technology to insert “reporter” genes into many species is well established. In particular, green fluorescent proteins (GFPs) and their genetically-modified variants ranging from blue to yellow, are easily spliced into many genomes at the sites of genes of interest (GoIs), where the GFPs are expressed with no apparent effect on the functioning of the proteins of interest (PoIs) coded for by the GoIs. One goal of biologists is more precise localization of PoIs within cells. The invention is a method and system for enabling more rapid and precise PoI localization using charged particle beam-induced damage to GFPs. Multiple embodiments of systems for implementing the method are presented, along with an image processing method relatively immune to high statistical noise levels.
First claim
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We claim as follows: 1. A charged particle system, comprising: a charged particle optical column for directing a charged particle beam onto a sample; a secondary electron detector for collecting secondary electrons emitted from the sample upon impact of the charged particle beam; a light detector for detecting light emitted by the sample; and an electrically conductive mirror, the mirror configured to: reflect toward the light detector the light emitted from the sample; and…
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Electricity · mapped topic
Physics · mapped topic
Electricity · mapped topic
Electricity · mapped topic
Electricity · mapped topic
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- What does patent US9040909B2 cover?
- A method and system for the imaging and localization of fluorescent markers such as fluorescent proteins or quantum dots within biological samples is disclosed. The use of recombinant genetics technology to insert “reporter” genes into many species is well established. In particular, green fluorescent proteins (GFPs) and their genetically-modified variants ranging from blue to yellow, are easil…
- Who is the assignee on this patent?
- Fei Co
- What technology area does this patent fall under?
- Primary CPC classification G01N21/6428. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue May 26 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).