Preparation of saturated ketone morphinan compounds

US9040705B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9040705-B2
Application numberUS-75709810-A
CountryUS
Kind codeB2
Filing dateApr 9, 2010
Priority dateApr 9, 2009
Publication dateMay 26, 2015
Grant dateMay 26, 2015

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Abstract

Official abstract text for this publication.

The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.

First claim

Opening claim text (preview).

What is claimed is: 1. A one-pot process for the preparation of a morphinan comprising a saturated ketone ring moiety, the process comprising contacting a morphinan comprising an allyl alcohol ring moiety with an inorganic salt of a late transition metal in the presence of a protic solvent, wherein the allyl alcohol ring moiety is catalytically isomerized to the saturated ketone ring moiety, and wherein the weight:weight ratio of the protic solvent to the morphinan comprising an al…

Assignees

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Classifications

  • Chemistry & Metallurgy · mapped topic

  • C07D489/04Primary

    Chemistry & Metallurgy · mapped topic

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What does patent US9040705B2 cover?
The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.
Who is the assignee on this patent?
Wang Peter X, Jiang Tao, Gurusamy Narayanasamy, and 2 more
What technology area does this patent fall under?
Primary CPC classification C07D489/04. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue May 26 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).