Oxycodone compositions
US-9522919-B2 · Dec 20, 2016 · US
US9040705B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9040705-B2 |
| Application number | US-75709810-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 9, 2010 |
| Priority date | Apr 9, 2009 |
| Publication date | May 26, 2015 |
| Grant date | May 26, 2015 |
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The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.
Opening claim text (preview).
What is claimed is: 1. A one-pot process for the preparation of a morphinan comprising a saturated ketone ring moiety, the process comprising contacting a morphinan comprising an allyl alcohol ring moiety with an inorganic salt of a late transition metal in the presence of a protic solvent, wherein the allyl alcohol ring moiety is catalytically isomerized to the saturated ketone ring moiety, and wherein the weight:weight ratio of the protic solvent to the morphinan comprising an al…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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