Process for the preparation of chiral triazolones

US9040539B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9040539-B2
Application numberUS-201113697806-A
CountryUS
Kind codeB2
Filing dateMay 18, 2011
Priority dateMay 19, 2010
Publication dateMay 26, 2015
Grant dateMay 26, 2015

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Abstract

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A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y 3 —NH 2 ; of formula (IIa) 0=C═N—Y 0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).

First claim

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The invention claimed is: 1. An optionally crystalline chiral compound of formula (IVa) or a salt thereof, wherein R 1 is an alkyl residue having from 1 to 6 carbon atoms and wherein —R is —H or the hydroxyl protecting group —SiR a R b R c , where R a , R b and R c are the same or different and selected from the group consisting of optionally suitably substituted a…

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What does patent US9040539B2 cover?
A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y 3 —NH 2 ; of formula (IIa) 0=C═N—Y 0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).
Who is the assignee on this patent?
Oberhuber Michael, Salchenegger Joerg, De Souza Dominic, and 6 more
What technology area does this patent fall under?
Primary CPC classification C07D295/155. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue May 26 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).