Beta-lactamase inhibitors

Patent metadata

Field	Value
Publication number	US-9040504-B2
Application number	US-201414152916-A
Country	US
Kind code	B2
Filing date	Jan 10, 2014
Priority date	Jan 10, 2013
Publication date	May 26, 2015
Grant date	May 26, 2015

Abstract

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

First claim

What is claimed is:

1. A compound of Formula (I) or Formula (Ia), or a pharmaceutically acceptable salt, polymorph, solvate, N-oxide, or isomer thereof:

wherein:
M is a bond, —O—, —S—, —S(O)—, SO 2 —, or —N(R 4 )—;
m is 0, 1, or 2;
n is 0, 1, 2, or 3;
provided that
when n is 0, then M is a bond;

p is 2;
X 1 and X 2 are independently selected from —OH, —OR…

Assignees

• Venatorx Pharmaceuticals Inc

Inventors

• Burns Christopher J
• Daigle Denis
• Liu Bin
• Mcgarry Daniel
• Pevear Daniel C
• Trout Robert E Lee
• Jackson Randy W

Classifications

• A61P31/04

  Human Necessities · mapped topic

• C07F5/025 Primary

  Chemistry & Metallurgy · mapped topic

• A61K31/496

  Human Necessities · mapped topic

• A61K31/546

  Human Necessities · mapped topic

• A61K31/69

  Human Necessities · mapped topic