Composition comprising longan arillus extract or combined extract comprising the same for treating neurodegenerative disease

Patent metadata

Field	Value
Publication number	US-9040102-B2
Application number	US-201113031751-A
Country	US
Kind code	B2
Filing date	Feb 22, 2011
Priority date	Jun 24, 2010
Publication date	May 26, 2015
Grant date	May 26, 2015

Abstract

This disclosure relates to a composition for prevention or treatment of neurodegenerative disease comprising longan arillus extract, or combined extract comprising longan arillus. The composition exhibits remarkably excellent prevention or treatment effect of neurodegenerative disease by containing longan arillus extract or combined extract comprising longan arillus, and particularly, it may effectively prevent or treat neurodegenerative disease by significantly protecting dopaminergic neurons from neurotoxicity due to MPTP selectively acting on dopaminergic nervous system and neurotoxicity due to aggregation of alpha-synuclein proteins.

First claim

What is claimed is:

1. A method for treating Parkinson's disease in a patient in need thereof comprising administering to the patient a composition comprising effective amounts of a Longan arillus extract, a Polygalae radix extract and an Angelicae tenuissumae radix extract,
wherein the extracts are obtained using at least one solvent selected from the group consisting of water, ethanol, propanol, and butanol.

2. The method according to claim 1 , wherein the extract combination further comprises at least one extract selected from the group consisting of Puerariae radix extract, Scutellaria radix extract, Platycodi radix extract, Angelicae Dahuricae radix extract, Cimicifugae Rhizoma extract, Raphani Semen extract, and Acorus Gramineri Rhizoma extract.

3. The method according to claim 2 , wherein the composition comprises the extracts in the following amounts: 15-20 parts by weight of Longan arillus, 10 to 15 parts by weight of Angelicae tenuissimae radix, 10 to 15 parts by weight of Polygalae radix, 15 to 20 parts by weight of Puerariae radix, 5 to 10 parts by weight of Scutellaria radix, 1 to 5 parts by weight of Platycodi radix, 5 to 10 parts by weight of Angelicae Dahuricae radix, 5 to 10 parts by weight of Cimicifugae Rhizoma, 5 to 10parts by weight of Raphani Semen and 15 to 20 parts by weight of Acorus Gramineri Rhizoma.

4. The method according to claim 2 , wherein each of the at least one extract is obtained using at least one extraction solvent selected from the group consisting of water, at least one organic solvent selected from C1-4 lower alcohol, hexane, methylene chloride, acetonitrile and acetone, and a mixed solvent thereof.

Assignees

• Yang Hyun-Ok
• Bae Na-Young
• Kwon Hak-Cheol
• Chung Sung-Kwon
• Oh Myung-Sook
• Korea Inst Sci & Tech

Inventors

• Yang Hyun-Ok
• Bae Na-Young
• Kwon Hak-Cheol
• Chung Sung-Kwon
• Oh Myung-Sook

Classifications

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61K36/539

  Scutellaria (skullcap) · CPC title

• A61K36/31

  Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi · CPC title

• A61P21/00

  Drugs for disorders of the muscular or neuromuscular system · CPC title