Anti-senstivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent

Patent metadata

Field	Value
Publication number	US-9040025-B2
Application number	US-38097109-A
Country	US
Kind code	B2
Filing date	Mar 5, 2009
Priority date	Feb 21, 2003
Publication date	May 26, 2015
Grant date	May 26, 2015

Abstract

This invention relates to a composition useful as a dentifrice comprising a surfactant agent consisting essentially of monoalkyl and dialkyl phosphate esters, wherein the ratio of monoesters to diesters is greater than 1, and optionally an abrasive agent consisting essentially of siliceous materials.

First claim

What is claimed is:

1. An oral care composition, comprising:
water soluble phosphate ester salts;
at least one anti-caries agent selected from the group consisting of sodium fluoride and sodium monofluorophosphate,
an abrasive agent, provided that the abrasive agent is not a calcium based abrasive agent, and
a peroxide tooth whitening agent,
wherein the composition has an absence of calcium compounds;
wherein all water soluble phosphate ester salts of the composition consist of one or more water soluble phosphate monoester salts according to structure (I) and one or more water soluble phosphate diester salts according to structure (II), wherein the molar ratio of said one or more monoester salts to said one or more diester salts is from 70:30 to 92:8:

wherein the phosphate monoester salt according to structure (I) has a phosphate head group of structure (IA)

and a hydrophobic tail of structure (IB)
R 1 O(C n H 2n O) a (C m H 2m O) b   (IB); and

wherein the dialkyl phosphate ester salt according to structure (II) has a phosphate head group of structure (IIA)

and hydrophobic tails of structures (IIB) and (IIC)
R 2 O(C n H 2n O) a (C m H 2m O) b   (IIB),

(OC m H 2m ) b (OC n C 2n ) a OR 3   (IIC);

wherein:
R 1 , R 2 , and R 3 are each individually linear or branched, saturated or unsaturated hydrocarbon groups of from 10 to 22 carbon atoms,
n and m are each individually 2 to 4,
a and b are each individually 0 to 20,
one of Z 1 and Z 2 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and the other of Z 1 and Z 2 is hydrogen, alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and
Z 3 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid;
wherein the phosphate head groups of the at least one monoalkyl water soluble phosphate ester salt and the at least one dialkyl water soluble phosphate ester salt are for anchoring to calcium hydroxyapatite tooth structure of a tooth, the hydrophobic tails for separating from the respective anchored phosphate head groups by hydrolysis, and the phosphate head groups after hydrolysis for being fixed in place in the calcium hydroxyapatite tooth structure by reaction with calcium in saliva of an oral cavity in which the tooth is located.

2. The composition of claim 1 , wherein said molar ratio of the one or more monoester salts to the one or more diester salts is from 70:30 to 91:9.

3. The composition of claim 1 , wherein R 1 , R 2 , and R 3 are each individually linear or branched, saturated or unsaturated hydrocarbon groups of from 10 to 14 carbon atoms, and said phosphate ester salts each have a degree of ethoxylation or propoxylation from 0 to 4.

4. The composition of claim 1 , wherein at least one said phosphate ester salt is alkyl ethoxylate phosphate ester salt having a degree of ethoxylation between 1 to 20.

5. The composition of claim 3 , wherein at least one of said phosphate ester salts is potassium dodecyl phosphate.

6. The composition of claim 1 , wherein the abrasive agent is selected from hydrated silica, colloidal silica, fumed silica, insoluble sodium metaphosphate, insoluble sodium aluminosilicates, sodium bicarbonate and mixtures thereof, wherein said abrasive agent is in amount of from about 5% to about 70% by weight of the composition.

7. The composition of claim 1 , wherein said composition is a toothpaste or a tooth cleaning gel.

8. The composition of claim 1 , wherein the composition further comprises a liquid selected from water, humectant, binder, and mixtures thereof, wherein said liquid is in an amount of from about 10% to about 90% by weight of the composition.

9. The composition of claim 1 , wherein said R 1 , R 2 , and R 3 are each individually linear or branched, saturated or unsaturated hydrocarbon groups of from 12 to 22 carbon atoms.

10. The composition of claim 9 , wherein R 1 , R 2 , and R 3 are each individually linear or branched, saturated or unsaturated hydrocarbon groups of from 12 to 14 carbon atoms.

11. The composition of claim 10 , wherein said phosphate ester salts have a degree of ethoxylation or propoxylation from 0 to 4.

12. An oral care composition consisting of:
one or more water soluble monoalkyl ester salts and one or more dialkyl phosphate ester salts, wherein the molar ratio of monoester salts to diester salts is from 70:30 to 92:8,
wherein from about 0.1 percent by weight to about 10 percent by weight of the composition is one or more of water soluble phosphate monoester salts according to structure (I) and one or more water soluble phosphate diester salts according to structure (II):

wherein the phosphate monoester salt according to structure (I) has a phosphate head group of structure (IA)

and a hydrophobic tail of structure (IB)
R 1 O(C n H 2n O) a (C m H 2m O) b   (IB); and

wherein the dialkyl phosphate ester salt according to structure (II) has a phosphate head group of structure (IIA)

and hydrophobic tails of structures (IIB) and (IIC)
R 2 O(C n H 2n O) a (C m H 2m O) b   (IIB),

(OC m H 2m ) b (OC n C 2n ) a OR 3   (IIC);

wherein:
R 1 , R 2 and R 3 are each individually linear or branched, saturated or unsaturated hydrocarbons of from 10 to 22 carbon atoms;
n and m of the monoalkyl ester and the dialkyl ester are each individually 2 to 4;
a and b of the monoalkyl ester and the dialkyl ester are each individually 0 to 20;
one of Z 1 and Z 2 is alkali metal, an ammonium, protonated alkyl amine, protonated alkanolamine or a protonated basic amino acid; and the other of Z 1 or Z 2 is hydrogen, alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid;
Z 3 is alkali metal, ammonium, protonated alkyl amine, protonated alkanolamine, or protonated basic amino acid, and
an abrasive agent, provided the abrasive agent is not a calcium based abrasive agent, wherein the abrasive agent is selected from at least one member of the group consisting of siliceous materials, insoluble sodium metaphosphate, insoluble sodium aluminosilicates, sodium bicarbonate, hydrated silica, colloidal silica, fumed silica;
a peroxide tooth whitening agent;
anti-caries agent selected from at least one member of the group consisting of sodium fluoride and sodium monofluorophosphate, wherein sodium trimetaphosphate is an optional additional anti-caries agent;
at least one additive selected from the group consisting of flavoring agent, sweetening agent, anti-calculus agent, buffering agent, and flow aids, alcohol, sudsing agent, preservatives, vitamins, anti-plaque agents, anti-staining compounds, anionic polymers, organic binder, inorganic thickener, nonionic surfactants, coloring agents, pigments, and tetrasodium pyrophosphate;
wherein the sweetening agent is at least one of saccharin and sorbitol;
wherein the anti-calculus agents are at least one of water soluble a

Assignees

• Reierson Robert Lee
• Domke Todd William
• Rhodia Operations

Inventors

• Reierson Robert Lee
• Domke Todd William

Classifications

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K8/55 Primary

  Phosphorus compounds · CPC title