Methods for treatment of cancer with an anti-tigit antagonist antibody
US-2024424092-A1 · Dec 26, 2024 · US
US9034643B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9034643-B2 |
| Application number | US-201213691356-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 30, 2012 |
| Priority date | Jun 4, 2003 |
| Publication date | May 19, 2015 |
| Grant date | May 19, 2015 |
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The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
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What is claimed is: 1. A polynucleotide sequence comprising a sequence selected from the group consisting of: (a) a polynucleotide sequence encoding SEQ ID NO:14; (b) a polynucleotide sequence encoding from amino acid 1 through amino acid 167 of SEQ ID NO:14; (c) SEQ ID NO:13; and (d) nucleotide 1 through nucleotide 501 of SEQ ID NO:13. 2. A recombinant polynucleotide comprising the polynucleotide sequence of claim 1 operably linked to a vector sequen…
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