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Targeting rare human PCSK9 variants for cholesterol treatment
US9034331B1 · US · B1
| Field | Value |
|---|---|
| Publication number | US-9034331-B1 |
| Application number | US-201414490112-A |
| Country | US |
| Kind code | B1 |
| Filing date | Sep 18, 2014 |
| Priority date | Jul 15, 2014 |
| Publication date | May 19, 2015 |
| Grant date | May 19, 2015 |
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Abstract
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The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
First claim
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I claim: 1. A method of reducing cholesterol level or maintaining previously reduced cholesterol level in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds a proprotein convertase subtilisin/kexin type 9 (PCSK9) that comprises a C-terminal domain comprising a mutation selected from the group consisting of: I474V; E670G; N425S; and Q619P in SEQ ID NO: 1, wherein the antibody or fragment comprises a…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K16/40Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9034331B1 cover?
- The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
- Who is the assignee on this patent?
- Kymab Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 19 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).