Asgpr-binding compounds for the degradation of extracellular proteins
US-2024424108-A1 · Dec 26, 2024 · US
US9029639B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9029639-B2 |
| Application number | US-201013382225-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 1, 2010 |
| Priority date | Jul 6, 2009 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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The present invention relates to pyridazine compounds of formulae I or II and the salts and N-oxides thereof, wherein A is a substituted or unsubstituted oxazole or thiazole or imidazole radical; V is C(R v ) or N; W is C(R w ) or N; with the proviso that either V or W is N; R t , R u , R v , R w are H, halogen, C 1 -C 4 -alkyl and the like; X 1 is S, O or NR 1a , wherein R 1a is selected H, C 1 -C 10 -alkyl and the like; X 2 is OR 2a , NR 2b R 2c , S(O) m R 2d , wherein m is 0, 1 or 2, R 2a is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, R 2b , R 2c are H, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl and the like, or R 2b and R 2c together with the nitrogen atom to which they are bound form a heterocycle, and R 2d is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl and the like; and R 1 is H, CN, C 1 -C 10 -alkyl and the like. The present invention further relates to a method for controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material, comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites and to an agricultural composition containing at least one compound according to the present invention.
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The invention claimed is: 1. A compound of formula (I) wherein A is an oxazole or thiazole or imidazole radical of formulae A1, A2 or A3, wherein # denotes the binding site to the remainder of formula I; Z is O or S for…
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