Linked purine pterin HPPK inhibitors useful as antibacterial agents

Patent metadata

Field	Value
Publication number	US-9029344-B2
Application number	US-201113704857-A
Country	US
Kind code	B2
Filing date	Jun 1, 2011
Priority date	Jun 18, 2010
Publication date	May 12, 2015
Grant date	May 12, 2015

Abstract

The disclosure provides linked purine pterin compounds and analogs thereof that are novel HPPK inhibitors. The HPPK inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general Formula I

The variables, e.g. A 1 to A 3 , R 1 to R 4 , L 1 , L 2 , B 1 , and B 2 are described herein. Compounds and salts of Formula I bind to HPPK with high affinity and specificity. Pharmaceutical compositions containing an HPPK inhibitor of Formula I and methods of treating a bacterial infection in a patient by providing one or more HPPK inhibitors of Formula I to the patient are also provided. Processes and intermediates useful for preparing compounds of Formula I are also provided. Methods of using the disclosed compounds to guide the development of additional novel anti-bacterial agents are also provided.

First claim

We claim:

1. A compound or pharmaceutically acceptable salt thereof of the formula:

wherein:

is a 5 or 6-membered heterocyclic ring;
X is nitrogen, —N(A 5 )-, —C(A 6 )-, or —C(A 6 A 7 )-;
A 1 is hydrogen, oxo, amino, or aminoC 1 -C 2 alkyl;
A 2 is absen…

Assignees

• Shi Genbin
• Shaw Gary X
• Ji Xinhua
• Us Health

Inventors

• Shi Genbin
• Shaw Gary X
• Ji Xinhua

Classifications

• C07D475/04

  Chemistry & Metallurgy · mapped topic

• C07H19/16 Primary

  Chemistry & Metallurgy · mapped topic

• G16B15/00

  Physics · mapped topic

• A61P31/00

  Human Necessities · mapped topic

• C07H19/167 Primary

  Chemistry & Metallurgy · mapped topic