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Glycopegylated granulocyte colony stimulating factor
US9029331B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9029331-B2 |
| Application number | US-79456006-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 10, 2006 |
| Priority date | Jan 10, 2005 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are purified using various chromatography methods.
First claim
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What is claimed is: 1. A method of preparing a purified, pegylated GCSF peptide, which method comprises (a) providing a composition comprising water, a buffer, at least one polysorbate, and 20 mM L-methionine, wherein the polysorbate is polyoxyethylene sorbitan monolaurate or polyoxvethylene sorbitan monooleate, and the composition has a pH of about 6.5; (b) combining the composition of step (a) with reagents comprising GCSF, GalNAeT2, and UDP-GalNAc, wherein the composition of…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9029331B2 cover?
- The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are purified using various chromatography methods.
- Who is the assignee on this patent?
- Defrees Shawn, Clausen Henrik, Zopf David A, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/535. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).