Methods and compositions for cancer treatment
US-2024424094-A1 · Dec 26, 2024 · US
Lipase variants for pharmaceutical use
US9029115B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9029115-B2 |
| Application number | US-201213587043-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 16, 2012 |
| Priority date | Dec 21, 2006 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The pharmaceutical use of lipases related to the Thermomyces lanuginosus ( Humicola lanuginosa ) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have, e.g., an improved digestion performance in vitro, an improved activity at a pH in the neutral range, an improved stability at low pH, and are stable against protease-degradation, and/or are stable in the presence of pepsin and bile salts. The invention also relates to methods of determining digestion performance in vitro of lipases, as well as to certain novel variants of the lipase of T. lanuginosus.
First claim
Opening claim text (preview).
The invention claimed is: 1. An isolated variant lipase which (a) has at least 90% identity to the sequence of amino acids 1-269 of SEQ ID NO: 2; (b) has lipase activity; and which, (c) as compared to the sequence of amino acids 1-269 of SEQ ID NO: 2, comprises substitutions N33Q+T231R+N233R and at least one substitution selected from the following: G38A,D,F,H,I,K,L,M,N,P,Q,S,T,W,Y; and G163A,C,D,E,H,I,K,L,M,N,P,Q,R,S,T,V,W,Y. 2. The isolated variant lipa…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9029115B2 cover?
- The pharmaceutical use of lipases related to the Thermomyces lanuginosus ( Humicola lanuginosa ) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.…
- Who is the assignee on this patent?
- Svendsen Allan, Skjoet Michael, Yaver Deborah, and 7 more
- What technology area does this patent fall under?
- Primary CPC classification A61K38/465. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).