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Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
US9028863B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9028863-B2 |
| Application number | US-83552004-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 26, 2004 |
| Priority date | Apr 25, 2003 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.
First claim
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The invention claimed is: 1. A resorbable unagglomerated nanoparticle drug delivery vehicle for delivering a growth-arresting lipid-derived bioactive compound and/or a hydrophobic chemotherapeutic agent and/or gene therapy agent to an animal or human in need of such delivery, comprising a dispersant attached to a calcium phospho-silicate shell encapsulating the lipid-derived compound, hydrophobic chemotherapeutic agent or gene therapy agent, wherein the lipid-derived compound is se…
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- A61K31/164Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Cross-Sectional Technologies · mapped topic
Human Necessities · mapped topic
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- What does patent US9028863B2 cover?
- A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which …
- Who is the assignee on this patent?
- Kester Mark, Stover Thomas, Lowe Tao, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/164. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).