Method for producing hematopoietic stem cells using pyrazole compounds
US-9212348-B2 · Dec 15, 2015 · US
Methods for promoting HSC self-renewal
US9028811B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9028811-B2 |
| Application number | US-201213431563-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 27, 2012 |
| Priority date | Mar 24, 2006 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E 2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
First claim
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The invention claimed is: 1. A method for promoting hematopoietic stem cell (HSC) self-renewal in a human subject in need thereof, comprising contacting a population of human HSCs ex vivo with an effective amount of 16,16-dimethyl-PGE2 to promote HSC self-renewal in the subject; and intravenously administering the contacted HSCs to the subject, wherein the population of human HSCs is autologous or allogeneic to the subject. 2. The method of claim 1 , where…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- C12N5/0647Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9028811B2 cover?
- The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E 2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, H…
- Who is the assignee on this patent?
- Zon Leonard I, North Trista E, Goessling Wolfram, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0647. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).