Chemical Synthesis Method of Plesiomonas Shigelloides Serotype O51 O-antigen Oligosaccharide
US-2019233459-A1 · Aug 1, 2019 · US
US9028809B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9028809-B2 |
| Application number | US-201013511652-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 24, 2010 |
| Priority date | Nov 24, 2009 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
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What is claimed is: 1. An immunogenic composition comprising: one or more constructs of live attenuated, modified vaccinia Ankara (MVA) viruses encoding: at least one V 307 peptide which is the C-terminally truncated low-calcium response V (LcrV) protein antigen of Yersinia pestis lacking its C-terminal amino acids 308 to 326 and a mammalian secretory signal sequence and a viral translational control sequence, wherein the mammalian secretory signal sequence is tissue plasmi…
Human Necessities · mapped topic
Human Necessities · mapped topic
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