Colon-targeted active agent delivery carrier and uses thereof
US-2024390501-A1 · Nov 28, 2024 · US
Method for impregnation with supercritical CO2
US9028806B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9028806-B2 |
| Application number | US-201013320453-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 12, 2010 |
| Priority date | May 15, 2009 |
| Publication date | May 12, 2015 |
| Grant date | May 12, 2015 |
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Abstract
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The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterized in that said method includes the following consecutive steps: a) mixing the active substance and the nonporous polymer pharmaceutical carrier, the pharmaceutical carrier being in a solid form and insoluble in supercritical CO 2 and not being non-crosslinked polyvinylpyrrolidone; b) performing a step of molecular diffusion in the absence of water by contacting, in a static mode without agitation, the mixture obtained in step a) with supercritical CO 2 at a pressure of 80 to 170 bars, at a temperature of 31 to 90° C. for 1 to 6 hours; c) recovering the polymer pharmaceutical carrier impregnated with the active substance obtained in step b), the impregnated pharmaceutical carrier being nonporous and being in a solid form and the active substance being in an amorphous form, the method being implemented in the absence of an additional solvent. The invention further relates to a polymer pharmaceutical carrier in a nonporous solid form impregnated with an active substance characterized in that said carrier can be obtained by the method according to the present invention, in that the active substance is in an amorphous form and is water-soluble, and in that the polymer pharmaceutical carrier is not non-crosslinked polyvinylpyrrolidone and is insoluble in supercritical CO 2 .
First claim
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The invention claimed is: 1. Batch method for impregnating a polymeric pharmaceutical carrier with an active substance, wherein it comprises the following consecutive steps: a) mixing the active substance and the non-porous polymeric pharmaceutical carrier chosen from disintegrating agents, filler agents, or mixtures thereof, the pharmaceutical carrier being in solid form and insoluble in supercritical CO 2 and not being non-cross-linked polyvinylpyrrolidone; b) performing a mo…
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- What does patent US9028806B2 cover?
- The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterized in that said method includes the following consecutive steps: a) mixing the active substance and the nonporous polymer pharmaceutical carrier, the pharmaceutical carrier being in a solid form and insoluble in supercritical CO 2 and not being non-cr…
- Who is the assignee on this patent?
- Lochard Hubert, Freiss Bernard, Pf Medicament
- What technology area does this patent fall under?
- Primary CPC classification A61K9/1694. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 12 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).