Materials and methods useful to induce cell death via methuosis

Patent metadata

Field	Value
Publication number	US-9028796-B2
Application number	US-201214001313-A
Country	US
Kind code	B2
Filing date	Feb 24, 2012
Priority date	Feb 24, 2011
Publication date	May 12, 2015
Grant date	May 12, 2015

Abstract

The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.

First claim

What is claimed is:

1. A compound having the structure of Formula I:

wherein X and Y are independently absent or halogen, oxygen, azide, nitrogen, (CO)O, O(CO), O(CO)O, (CO)N, NH(CO), NH(CO)N, NH(CO)O, or O(CO)N;
wherein when X or Y is halogen or azide, then R is absent, and
wherein when X or Y is nitrogen, (CO)N, O(CO)N, or NH(CO)N, then two R groups are pr…

Assignees

• Maltese William A
• Erhardt Paul W
• Robinson Michael W
• Overmeyer Jean H
• Univ Toledo

Inventors

• Maltese William A
• Erhardt Paul W
• Robinson Michael W
• Overmeyer Jean H

Classifications

• A61K45/06

  Human Necessities · mapped topic

• C07D209/08

  Chemistry & Metallurgy · mapped topic

• C07D403/06

  Chemistry & Metallurgy · mapped topic

• C07D209/12

  Chemistry & Metallurgy · mapped topic

• A61K31/404 Primary

  Human Necessities · mapped topic