Method for expressing and purifying protein by using csq-tag
US-2024209046-A1 · Jun 27, 2024 · US
Hydrophobic interaction chromatography purification of factor VII polypeptides
US9023992B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9023992-B2 |
| Application number | US-88492710-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 17, 2010 |
| Priority date | May 4, 2004 |
| Publication date | May 5, 2015 |
| Grant date | May 5, 2015 |
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Abstract
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The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
First claim
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The invention claimed is: 1. A process for reducing the content of forms of activated Factor VII lacking one or more N-linked glycan(s) in a drug substance of a recombinantly made activated Factor VII polypeptide, said process comprising the steps of: (a) contacting the drug substance with a hydrophobic interaction chromatography material comprising a butyl ligand and/or phenyl ligand under conditions which facilitate binding of a portion of said drug substance to said hydrophobic…
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Human Necessities · mapped topic
Human Necessities · mapped topic
- C07K14/745Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9023992B2 cover?
- The invention described herein provides new methods of preparing purified Factor VII polypeptide drug substances in large quantities (industrial scale levels) that are associated with reduced content of product-related impurities (e.g., late eluting peaks) and/or that exhibit a relatively uniform glycosylation pattern.
- Who is the assignee on this patent?
- Rasmussen Daniel E, Krarup Janus, Novo Nordisk Healthcare Ag
- What technology area does this patent fall under?
- Primary CPC classification C07K14/745. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).