Introduction of alkyl substituents to aromatic compounds
US-10351492-B2 · Jul 16, 2019 · US
Compound for use in peptide synthesis
US9023957B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9023957-B2 |
| Application number | US-201113808303-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 6, 2011 |
| Priority date | Jul 6, 2010 |
| Publication date | May 5, 2015 |
| Grant date | May 5, 2015 |
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Abstract
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The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-terminal tertiary N,N-bis(2-mercaptoethyl)-amide (BMEA) undergo N-to-S acyl transfer at weakly acidic pH to form a transient thioester which can be captured for direct ligation with a cysteinyl peptide. These C-terminal BMEA peptides are easily prepared with standard Fmoc solid-phase synthesis protocols, thus giving a very convenient access to the thioester components for native chemical ligation.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of peptide synthesis comprising a step of reacting a compound to form a polypeptide or protein, the compound having the following structural formula: wherein n is 2 or 3; m is 2 or 3; and RC(O)— is an amino acyl or peptidyl group, or R is selected from the group consisting of hydrogen, oxygen, sulfur, alkyl, al…
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Classifications
- C07C323/29Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K1/1077Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9023957B2 cover?
- The present invention generally relates to processes and methods of peptide and protein synthesis. The present invention also relates to specific compounds for use in such processes and methods. It is shown herein that peptides with a C-terminal tertiary N,N-bis(2-mercaptoethyl)-amide (BMEA) undergo N-to-S acyl transfer at weakly acidic pH to form a transient thioester which can be captured for…
- Who is the assignee on this patent?
- Liu Chuan Fa, Univ Nanyang Tech
- What technology area does this patent fall under?
- Primary CPC classification C07C323/29. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).