Cellobiohydrolase variants
US-9260705-B2 · Feb 16, 2016 · US
Enhanced citric acid production in Aspergillus with inactivated asparagine-linked glycosylation protein 3 (Alg3), and/or increased LaeA expression
US9023637B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9023637-B2 |
| Application number | US-201213691396-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 30, 2012 |
| Priority date | Nov 30, 2011 |
| Publication date | May 5, 2015 |
| Grant date | May 5, 2015 |
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Abstract
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Provided herein are fungi, such as Aspergillus niger , having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (Lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclosed fungi to make citric acid are also provided, as are compositions and kits including the disclosed fungi.
First claim
Opening claim text (preview).
We claim: 1. An isolated fungus comprising a genetic inactivation of an endogenous dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene, wherein the fungus is an Aspergillus species and the Alg3 gene is genetically inactivated by complete or partial deletion mutation or by insertional mutation, wherein the endogenous Alg3 gene prior to the genetic inactivation encodes a protein having at least 80% sequence identity to the polypeptide of SEQ ID NO: 2 or 4.…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12P7/48Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9023637B2 cover?
- Provided herein are fungi, such as Aspergillus niger , having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of aflR expression A (Lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain. Methods of using the disclose…
- Who is the assignee on this patent?
- Battelle Memorial Institute
- What technology area does this patent fall under?
- Primary CPC classification C12P7/48. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).