Synthesis and isolation of dendrimer based imaging systems
US-2015352230-A1 · Dec 10, 2015 · US
In situ hybridization detection method
US9017992B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9017992-B2 |
| Application number | US-99357106-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 30, 2006 |
| Priority date | Jul 1, 2005 |
| Publication date | Apr 28, 2015 |
| Grant date | Apr 28, 2015 |
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Abstract
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The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detectable labels into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases allow for degenerate base pairing schemes. The compositions and methods are also compatible with immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry, enzyme immuno-assays (EIA), enzyme linked immuno-assays (ELISA), blotting methods (e.g. Western, Southern, and Northern), labeling inside electrophoresis systems or on surfaces or arrays, and precipitation, among other general detection assay formats. The invention is also compatible with many different types of targets, probes, and detectable labels.
First claim
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What is claimed is: 1. A composition comprising a recognition unit, a detection unit, and an adaptor unit, wherein: a) the recognition unit and the detection unit each comprises a hybridizing nucleic acid analog segment and the adaptor unit comprises a first hybridizing nucleic acid analog segment and a second hybridizing nucleic acid analog segment; b) the hybridizing nucleic acid analog segment of the recognition unit specifically hybridizes to the first hybridizing nucleic ac…
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- A61K49/0041Primary
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9017992B2 cover?
- The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target. The layers may be created by incorporating probes and detecta…
- Who is the assignee on this patent?
- Winther Lars, Lohse Jesper, Gabs Susanne, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K49/0041. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).