Methods for producing modified reverse transcriptases
US-2024124856-A1 · Apr 18, 2024 · US
DNA polymerases with improved activity
US9017979B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9017979-B2 |
| Application number | US-201213443721-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 10, 2012 |
| Priority date | Apr 11, 2011 |
| Publication date | Apr 28, 2015 |
| Grant date | Apr 28, 2015 |
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Abstract
Official abstract text for this publication.
Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.
First claim
Opening claim text (preview).
What is claimed is: 1. A recombinant DNA polymerase having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of reverse transcriptase (RT) and polymerase inhibitors compared with a control DNA polymerase, wherein the DNA polymerase has at least 98% amino acid sequence identity to SEQ ID NO: 1 and comprises a motif in the polymerase domain consisting of:…
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- C12N9/1276Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9017979B2 cover?
- Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells…
- Who is the assignee on this patent?
- Bauer Keith, Myers Thomas W, Reichert Fred, and 4 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1276. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).