Glyconjugate Vaccines
US-2024382585-A1 · Nov 21, 2024 · US
Sugar-chain modified yeast and method for producing glycoprotein using the same
US9017969B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9017969-B2 |
| Application number | US-201213409558-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 1, 2012 |
| Priority date | Jan 4, 2011 |
| Publication date | Apr 28, 2015 |
| Grant date | Apr 28, 2015 |
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Abstract
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The present invention provides: genetically modified yeasts such as mutant yeasts having an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 and a decreased ability to produce O-linked sugar chains, mutant yeasts having an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 and further having an ability to produce N-linked sugar chains of GlcNAc 1 Man 5 GlcNAc 2 , and mutant yeasts having an increased ability to produce and secrete proteins and an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 ; and a method for producing glycoproteins using them.
First claim
Opening claim text (preview).
What is claimed is: 1. A mutant yeast having an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 , wherein: (a) the yeast is functionally deficient in a protein-O-mannosyltransferase gene, an α-1,6-mannosyltransferase gene, an α-1,3 mannosyltransferase gene and a mannose-1-phosphorylation control gene; (b) the yeast has a decreased ability to produce O-linked sugar chains relative to a corresponding yeast that is not functionally deficient in a protein-O-mannosyltransf…
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- C12P21/005Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9017969B2 cover?
- The present invention provides: genetically modified yeasts such as mutant yeasts having an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 and a decreased ability to produce O-linked sugar chains, mutant yeasts having an ability to produce N-linked sugar chains of Man 5 GlcNAc 2 and further having an ability to produce N-linked sugar chains of GlcNAc 1 Man 5 GlcNAc 2 , and mutant …
- Who is the assignee on this patent?
- Abe Hiroko, Tomimoto Kazuya, Fujita Yasuko, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification C12P21/005. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).