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Reagents for probing ROCKs activation
US9017952B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9017952-B2 |
| Application number | US-201213686717-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 27, 2012 |
| Priority date | Jul 24, 2012 |
| Publication date | Apr 28, 2015 |
| Grant date | Apr 28, 2015 |
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Abstract
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A set of agents is provided for probing/detecting the activation of Rho-associated protein kinase I and II individually encoding their amino acid sequence (SEQ ID NO:1 for ROCKI and SEQ ID NO:2 for ROCKII) in biological samples. The agents include one antibody to specifically recognize ROCKI Ser 1333 phosphorylation and one antibody to specifically recognize ROCKII Ser 1366 phosphorylation. The agents can be used for pathological analysis in cardiovascular diseases, cancer, neurological diseases or other diseases/disorders involving ROCKs and also for basic medical research. Moreover, the agents can be used for screening inhibitors against ROCKI and II.
First claim
Opening claim text (preview).
What is claimed is: 1. A reagent for probing the activation of a Rho-associated protein kinase II (ROCKII) in a biological sample from a mammal, the ROCKII comprising a peptide-II sequence, wherein the reagent comprises an antibody-II that specifically binds to a phosphorylated serine amino acid at position 1366 in SEQ ID NO:2 but does not bind when serine amino acid at position 1366 in SEQ ID NO:2 is not phosphorylated. 2. The reagent according to claim 1 , wh…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
- C07K16/40Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9017952B2 cover?
- A set of agents is provided for probing/detecting the activation of Rho-associated protein kinase I and II individually encoding their amino acid sequence (SEQ ID NO:1 for ROCKI and SEQ ID NO:2 for ROCKII) in biological samples. The agents include one antibody to specifically recognize ROCKI Ser 1333 phosphorylation and one antibody to specifically recognize ROCKII Ser 1366 phosphorylation. T…
- Who is the assignee on this patent?
- Univ Nat Yang Ming
- What technology area does this patent fall under?
- Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).