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US-2024316086-A1 · Sep 26, 2024 · US
Catalytic radiofluorination
US9017724B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9017724-B2 |
| Application number | US-63860609-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 15, 2009 |
| Priority date | Feb 24, 2004 |
| Publication date | Apr 28, 2015 |
| Grant date | Apr 28, 2015 |
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Abstract
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One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.
First claim
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We claim: 1. A method of making a radiofluorinated compound, represented by A-Y, by reacting a substrate, represented by A-X, with a radiofluorinating agent, represented by MY, wherein A is (i)a 5-, 6-, or 7-membered single-ring aromatic group that includes no heteroatoms in its ring structure, or (ii) a polycyclic ring system having two or more fused rings wherein at least one of the rings is a 5-, 6-, or 7-membered single-ring aromatic group that includes no heteroatoms in its r…
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Classifications
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C07F9/5442Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9017724B2 cover?
- One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary a…
- Who is the assignee on this patent?
- Elmaleh David R, Fischman Alan J, Shoup Timothy M, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07F9/5442. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).