Systems and methods for visualizing ablated tissue

Patent metadata

Field	Value
Publication number	US-9014789-B2
Application number	US-201213624899-A
Country	US
Kind code	B2
Filing date	Sep 22, 2012
Priority date	Sep 22, 2011
Publication date	Apr 21, 2015
Grant date	Apr 21, 2015

Abstract

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.

First claim

What is claimed is:

1. A catheter to image ablated endocardial heart muscle tissue comprising:
a balloon positioned about a distal end of the catheter, the balloon being inflatable with a transparent fluid for displacing surrounding blood to allow visualization of NADH fluorescence;
an ultra-violet illumination device disposed at the distal end of the catheter for exciting mitochondrial NADH of the pulmonary vein and left atrial tissue;
a fiberscope disposed at the distal end of the catheter for detecting NADH fluorescence from the illuminated pulmonary vein and left atrial tissue at the distal end; and
a fluorescence camera at the proximal end of the catheter for creating a fluorescence image from the detected NADH fluorescence captured by the fiberscope,
wherein the detected fluorescence image shows the physiology of the ablated lesion having a dark appearance due to lack of fluorescence, gaps having a light appearance due to normal fluorescence, and any ischemic tissue having a brighter halo type appearance surrounding the ablated lesion, and wherein the fluorescence camera includes a 460 nm band-pass filter to detect the NADH fluorescence from the illuminated pulmonary vein and left atrial tissue.

2. The catheter of claim 1 , wherein the fluorescence camera is a CCD camera.

3. The catheter of claim 1 , wherein the fiberscope is an optical imaging bundle.

4. A method for imaging a treated tissue comprising:
ablating a heart tissue;
illuminating, using an ultraviolet light source, the ablated tissue and untreated tissue around the ablated tissue to excite NADH in the tissue;
imaging fluorescence of NADH in the illuminated tissue to produce a display of the imaged, illuminated tissue, the display illustrating the ablated tissue as having less fluorescence than the untreated tissue around the ablated tissue;
distinguishing between the ablated tissue and ischemic tissue based on the amount of fluorescence; and
ablating additional ischemic tissue identified by distinguishing between ablated tissue and ischemic tissue based on the amount of fluorescence.

5. The method of claim 4 , wherein the step of illuminating comprises exciting mitochondrial NADH.

6. The method of claim 4 , wherein distinguishing between the ablated tissue and ischemic tissue is based on a dark appearance due to lack of fluorescence of the ablated tissue and a lighter appearance of the ischemic tissue.

7. The method of claim 4 further comprising capturing light emitted from the illuminated tissue.

8. The method of claim 4 further comprising imaging treated tissue in real time.

9. The method of claim 4 further comprising using the imaging of treated tissue forms as the basis for a repeat or therapeutic procedure or follow-up revision procedure.

Assignees

• Univ George Washington

Inventors

• Mercader Marco A
• Kay Matthew W
• Sarvazyan Narine

Classifications

• A61B5/0071 Primary

  by measuring fluorescence emission · CPC title

• A61B1/0676

  at distal tip of an endoscope · CPC title

• A61B1/00165

  with light-conductive means, e.g. fibre optics (A61B1/07 takes precedence) · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B2018/00982

  combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes · CPC title