Crystalline forms of Prasugrel salts

Patent metadata

Field	Value
Publication number	US-9012641-B2
Application number	US-201414337846-A
Country	US
Kind code	B2
Filing date	Jul 22, 2014
Priority date	Apr 8, 2010
Publication date	Apr 21, 2015
Grant date	Apr 21, 2015

Abstract

Salts of prasugrel were prepared including, for example, crystalline forms of prasugrel hydro bromide. These salts are useful, for example, in medicaments that inhibit the aggregation of platelets.

First claim

What is claimed is:

1. Anhydrous Prasugrel hydrobromide according to formula I:

2. A pharmaceutical composition comprising anhydrous Prasugrel hydrobromide according to Formula I

and at least one pharmaceutically acceptable excipient.

3. A method of producing a pharmaceutical composition comprising combining anhydrous Prasugrel hydrobromide according to Formula I

and at least one pharmaceutically acceptable excipient.

4. A method for inhibiting aggregation of platelets comprising administering a pharmaceutically effective amount of anhydrous Prasugrel hydrobromide according to Formula I

to a subject in need of such treatment.

Assignees

• Teva Pharma

Inventors

• Tuksar Mihaela
• Biljan Tomislav
• Zegarac Miroslav

Classifications

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• C07D495/04 Primary

  Ortho-condensed systems · CPC title