TARGET-BASED METHOD FOR HIGH-THROUGHPUT AND SUBCLASS SPECIFIC IgG GLYCAN PROFILING IN HUMAN PLASMA
US-2024353417-A1 · Oct 24, 2024 · US
Thyroglobulin quantitation by mass spectroscopy
US9012394B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012394-B2 |
| Application number | US-201314031678-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 19, 2013 |
| Priority date | Sep 20, 2012 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Abstract
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Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
First claim
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That which is claimed is: 1. A method for determining the amount of thyroglobulin in a test sample, comprising: (a) digesting thyroglobulin (Tg) and an added isotopically labeled thyroglobulin peptide standard in said test sample to form Tg peptides and Tg peptide standard products, wherein the Tg peptide standard has an amino acid sequence VIFDANAPVAVR (SEQ ID NO: 1 ), wherein one or more valine is isotopically labeled with 13 C, 15 N; (b) purifying said Tg peptides and Tg pe…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9012394B2 cover?
- Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129…
- Who is the assignee on this patent?
- Quest Diagnostics Invest Inc, Quest Diagnostics Invest Inc
- What technology area does this patent fall under?
- Primary CPC classification G01N33/6848. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).