Topical protective polymerized nanoparticles in an active or bioactive array, methods for preparing same and uses thereof
US-2015374610-A1 · Dec 31, 2015 · US
Polymer backbone element tags
US9012239B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012239-B2 |
| Application number | US-75434007-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 28, 2007 |
| Priority date | May 27, 2006 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Abstract
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Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).
First claim
Opening claim text (preview).
What is claimed is: 1. An element tag comprising: 1) a copolymer comprising N-N-dimethyl acrylamide and N-acryloxysuccinimide, the copolymer having a polydispersity index from 1.02 to 1.2; and 2) at least one metal-binding pendant group covalently attached to the copolymer, the metal-binding pendant group selected from the group consisting of a diethylenetriaminepentaacetate (DTPA) ligand, a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) ligand, and an amide or…
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Physics · mapped topic
Cross-Sectional Technologies · mapped topic
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9012239B2 cover?
- Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of m…
- Who is the assignee on this patent?
- Winnik Mitchell A, Nitz Mark, Baranov Vladimir, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C08F8/42. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).