Microorganisms genetically engineered to have modified N-glycosylation activity
US-9222083-B2 · Dec 29, 2015 · US
Chinese hamster ovary cell lines
US9012176B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012176-B2 |
| Application number | US-200913119461-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 18, 2009 |
| Priority date | Sep 19, 2008 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Abstract
Official abstract text for this publication.
We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of expressing a protein of interest from a Chinese Hamster Ovary (CHO) cell, the method comprising: (a) introducing a nucleic acid encoding a protein of interest into a mutant Chinese Hamster Ovary (CHO) cell, wherein said mutant CHO cell comprises: (i) a loss of function mutation in the N-Acetyl-glucosaminyltransferase I (GnT 1) gene, and (ii) an exogenous nucleic acid sequence encoding functional GnT I; and (b) allowing the protein of inte…
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- C12N9/1051Primary
Chemistry & Metallurgy · mapped topic
- C07K14/57Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9012176B2 cover?
- We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I (RCA-I).
- Who is the assignee on this patent?
- Song Zhiwei, Agency Science Tech & Res
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1051. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).