Bacterial colicin-immunity protein protein purification system
US-2024417426-A1 · Dec 19, 2024 · US
US9012152B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012152-B2 |
| Application number | US-52254508-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 8, 2008 |
| Priority date | Jan 9, 2007 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Isolated peptides comprising no more than ten amino acids and having anti-bacterial properties are disclosed. In one embodiment the peptides have a consensus amino acid sequence X 1 X 2 X 3 X 4 X 5 , wherein X 1 and X 5 comprise polar amino acids. In another embodiment, the peptides have a consensus amino acid sequence X 1 X 2 X 3 X 4 X 5 , wherein X 2 and X 4 are asparagine (N) residues and X 3 is tryptophan (W). Compositions comprising same are also disclosed and uses thereof.
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What is claimed is: 1. A method of killing bacteria which comprise the mazEF toxin-antitoxin module and which are in logarithmic growth, the method comprising contacting the bacteria with an effective amount of an isolated pentapeptide, comprising a consensus amino acid sequence X 1 X 2 X 3 X 4 X 5 , wherein both X 1 and X 5 comprise an amino acid independently selected from the group consisting of an asparagine residue and a glutamine residue wherein X 3 is a tryptophan residue…
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