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CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
US9012134B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9012134-B2 |
| Application number | US-75647907-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 31, 2007 |
| Priority date | May 31, 2006 |
| Publication date | Apr 21, 2015 |
| Grant date | Apr 21, 2015 |
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Abstract
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The invention provides methods of isolating CD127 lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
First claim
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What is claimed is: 1. A method of enriching a sample comprising T-cells for FoxP3 + immunosuppressive regulatory T-cells, the method comprising: providing the sample comprising T-cells, wherein the sample is a peripheral blood mononuclear cell (PBMC) sample; contacting the sample with a fluorescently labeled monoclonal CD4 antibody and a fluorescently labeled monoclonal CD127 antibody; and sorting the cells according to the amount of the fluorescently labeled CD4 and CD127 a…
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Human Necessities · mapped topic
- G01N33/505Primary
Physics · mapped topic
Human Necessities · mapped topic
- G01N33/56972Primary
Physics · mapped topic
Physics · mapped topic
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- What does patent US9012134B2 cover?
- The invention provides methods of isolating CD127 lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
- Who is the assignee on this patent?
- Bluestone Jeffrey A, Liu Weihong, Putnam Amy, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/505. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).