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US-2024417717-A1 · Dec 19, 2024 · US
Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use
US9000141B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9000141-B2 |
| Application number | US-89271410-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 28, 2010 |
| Priority date | Jul 27, 2004 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection.
First claim
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We claim: 1. An isolated nucleic acid molecule encoding a mutant flavivirus E-glycoprotein polypeptide comprising at least one amino acid substitution at position 104 or 106 compared to a wild type flavivirus E-glycoprotein polypeptide, wherein the mutant E-glycoprotein polypeptide exhibits reduced antibody cross-reactivity as compared to the wild type E-glycoprotein polypeptide, and wherein the flavivirus is selected from the group consisting of dengue serotype 1 virus, dengue ser…
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Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
- C07K14/005Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9000141B2 cover?
- Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detec…
- Who is the assignee on this patent?
- Chang Gwong-Jen J, Crill Wayne D, Us Health
- What technology area does this patent fall under?
- Primary CPC classification C07K14/005. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).