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Inhibitors of the renal outer medullary potassium channel
US8999991B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999991-B2 |
| Application number | US-201214353418-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2012 |
| Priority date | Oct 25, 2011 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
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What is claimed is: 1. A compound having structural Formula I: or a pharmaceutically acceptable salt thereof wherein: Z 1 is Z 2 is R 1 is —H, —CH 3…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US8999991B2 cover?
- The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and co…
- Who is the assignee on this patent?
- Tang Haifeng, Pio Barbara, Chobanian Harry R, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D405/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).