Modulators of cystic fibrosis transmembrane conductance regulator

Patent metadata

Field	Value
Publication number	US-8999976-B2
Application number	US-201314100748-A
Country	US
Kind code	B2
Filing date	Dec 9, 2013
Priority date	Dec 30, 2008
Publication date	Apr 7, 2015
Grant date	Apr 7, 2015

Abstract

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.

First claim

What is claimed is:

1. A compound of Formula IVD:

or pharmaceutically acceptable salts thereof, wherein:
W is a bond or is an optionally substituted C 1 -C 6 alkylidene chain wherein up to two methylene units of W are optionally and independently replaced by O, —CO—, —CS—, —COCO—, —CONR′—, —CONR′NR′—, —CO 2 —, —OCO—, —NR′CO 2 —, —O—, —NR′CONR′—, —C(O)NR′—, —OCONR′—, —NR…

Assignees

• Vertex Pharma

Inventors

• Binch Hayley
• Hurley Dennis
• Fanning Lev T D
• Grootenhuis Peter D J
• Botfield Martyn
• Van Goor Fredrick

Classifications

• A61P43/00

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic

• A61P7/00

  Human Necessities · mapped topic

• A61P7/04

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic