Compositions and methods for targeted delivery to cells
US-2024390271-A1 · Nov 28, 2024 · US
Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof
US8999927B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999927-B2 |
| Application number | US-201313855533-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 2, 2013 |
| Priority date | Apr 2, 2012 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Abstract
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Described herein is the identification of primate-specific glial cell line-derived neurotrophic factor opposite strand (GDNFOS) transcripts and encoded peptides. In particular embodiments, provided herein are three GDNFOS antisense transcripts, referred to as GDNFOS-1, GDNFOS-2 and GDNFOS-3. The GDNFOS-3 transcript encodes an ORF of 105 amino acids. Compositions comprising the GDNFOS transcripts and peptides are also provided by the present disclosure. Further provided are methods of treating a neurodegenerative or peripheral organ disease in a subject by administering a therapeutically effective amount of the disclosed GDNFOS nucleic acid molecules, peptides or compositions.
First claim
Opening claim text (preview).
The invention claimed is: 1. A fusion protein comprising a glial cell line-derived neurotrophic factor opposite strand (GDNFOS) peptide and a heterologous protein, wherein the GDNFOS peptide comprises an amino acid sequence at least 90% identical to SEQ ID NO: 4 or at least 90% identical to residues 29-105 of SEQ ID NO: 4. 2. The fusion protein of claim 1 , wherein the GDNFOS peptide comprises an amino acid sequence at least 95% identical to SEQ ID NO: 4 or at…
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- C07K14/47Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8999927B2 cover?
- Described herein is the identification of primate-specific glial cell line-derived neurotrophic factor opposite strand (GDNFOS) transcripts and encoded peptides. In particular embodiments, provided herein are three GDNFOS antisense transcripts, referred to as GDNFOS-1, GDNFOS-2 and GDNFOS-3. The GDNFOS-3 transcript encodes an ORF of 105 amino acids. Compositions comprising the GDNFOS transcript…
- Who is the assignee on this patent?
- Us Health
- What technology area does this patent fall under?
- Primary CPC classification C07K14/47. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).