System and methods for performing saliva-based diagnostic screenings
US-2024420847-A1 · Dec 19, 2024 · US
US8999728B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999728-B2 |
| Application number | US-201113332571-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 21, 2011 |
| Priority date | Dec 21, 2011 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device is a pregnancy test device, which detects human chorionic gonadotropin (hCG) as an indicator of pregnancy. Devices with improved clinical sensitivity are provided which are capable of detecting all clinically relevant hCG isoforms.
Opening claim text (preview).
The invention claimed is: 1. A device for detecting human chorionic gonadotropin (hCG) isoforms in a liquid sample, wherein the device comprises a substrate comprising a release medium formed of a first material and a capture medium formed of a second, different material, the substrate having deposited thereon: i) a first antibody that recognizes all clinically relevant hCG isoforms; ii) a second antibody that is specific for an epitope unique to hCG beta core fragment (hCG-βcf)…
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