Aqueous radiation protecting formulations and methods for making and using them

Patent metadata

Field	Value
Publication number	US-8999720-B2
Application number	US-201213660648-A
Country	US
Kind code	B2
Filing date	Oct 25, 2012
Priority date	Nov 17, 2011
Publication date	Apr 7, 2015
Grant date	Apr 7, 2015

Abstract

Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

First claim

The invention claimed is:

1. A method of inhibiting damage to a saccharide sensor that can result from a radiation sterilization process, the method comprising combining the saccharide sensor with an aqueous radioprotectant formulation during the sterilization process, wherein:
the saccharide sensor comprises a saccharide binding polypeptide having a carbohydrate recognition domain;
the aqueous radioprotectant formulation comprises a saccharide selected for its ability to bind t…

Assignees

• Medtronic Minimed Inc

Inventors

• Kristensen Jesper Svenning
• Aasmul Soren

Classifications

• A61L2103/15

  Human Necessities · mapped topic

• A61B2562/12

  Human Necessities · mapped topic

• A61B5/14532 Primary

  Human Necessities · mapped topic

• A61B5/14735

  Human Necessities · mapped topic

• A61B2562/18

  Human Necessities · mapped topic