Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity
US-2024426772-A1 · Dec 26, 2024 · US
US8999716B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8999716-B2 |
| Application number | US-201213592030-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 22, 2012 |
| Priority date | Feb 23, 2010 |
| Publication date | Apr 7, 2015 |
| Grant date | Apr 7, 2015 |
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Provided herein are artificial membranes of mycolic acids. The membranes may be unsupported or tethered. These membranes are long lived and highly resistant to electroporation, demonstrating their general strength. The mycolic acid membranes are suitable for controlled studies of the mycobacterial outer membrane and can be used in other experiments, such as nanopore analyte translocation experiments.
Opening claim text (preview).
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. An artificial bilayer membrane spanning the opening of an aperture, the membrane comprising a mycolic acid and having a rupture voltage greater than 0.5 V. 2. The membrane of claim 1 , wherein the mycolic acid is a crosslinked mycolic acid. 3. The membrane of claim 1 further comprising a nanopore. 4. The me…
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